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KMID : 0385219930030020075
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Korean Journal of Gerontology
1993 Volume.3 No. 2 p.75 ~ p.86
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Neurochemical correlates of ibotenic acid lesion of rat stratum - Anterograde transsynaptic degeneration of dopaminergic neurons in substantia nigra
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Woo Jong-In
Lee Chung-Kyun
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Abstract
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This study sought to characterize the neurochemical changes in the caudate nucleus(CN) and substantia nigra(SN) produced by unilateral microinjetion of the neurotoxin ibotenic acid(IBO) into the CN of rat brain, and to contrast them with those by 6-hydroxydopamine(6-OHDA) at various days after lesions. In the CN, IBO produced a rapid reduction to 35% and 34% of control (n=5-8, p<0.01) in choline acetyltransferase(CAT) and glutamate decarboxylase(GAD) activities, respectively. Tyrosine hydroxylase(TH) activity declined to 58-79% between days 21-56. In the SN, GAD activity decreased to 56% of control by day 14 and Th activity returned to control values by day 8. In the lesions by 6-OHDA, TH activity decreased that : (a) acutely, IBO lesions of the CN result in the rapid loss of intrinsic striatal GABAergic and cholinergic neurons, and the progressive degeneration of the striatonigral GABAergic pathway, (b) subacutely, there are gradual losses of DA terminals in the CN reflecting the partial death of DA neurons in the SN. The nature of this delayed process differs from the one by 6-OHDA. We conclude that the IBO lesions of the CN elicit the anterograde transsynaptic degeneration of nigrostrial DA neurons.
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KEYWORD
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ibotenic acid, 6-hydroxydopamine, caudate nucleus, substantia nigra, transsynaptic degeneration
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